EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structures of pseudorabies virus capsids.
ジャーナル・号・ページ	Nat Commun, Vol. 13, Issue 1, Page 1533, Year 2022
掲載日	2022年3月22日
著者	Guosong Wang / Zhenghui Zha / Pengfei Huang / Hui Sun / Yang Huang / Maozhou He / Tian Chen / Lina Lin / Zhenqin Chen / Zhibo Kong / Yuqiong Que / Tingting Li / Ying Gu / Hai Yu / Jun Zhang / Qingbing Zheng / Yixin Chen / Shaowei Li / Ningshao Xia /
PubMed 要旨	Pseudorabies virus (PRV) is a major etiological agent of swine infectious diseases and is responsible for significant economic losses in the swine industry. Recent data points to human viral ...Pseudorabies virus (PRV) is a major etiological agent of swine infectious diseases and is responsible for significant economic losses in the swine industry. Recent data points to human viral encephalitis caused by PRV infection, suggesting that PRV may be able to overcome the species barrier to infect humans. To date, there is no available therapeutic for PRV infection. Here, we report the near-atomic structures of the PRV A-capsid and C-capsid, and illustrate the interaction that occurs between these subunits. We show that the C-capsid portal complex is decorated with capsid-associated tegument complexes. The PRV capsid structure is highly reminiscent of other α-herpesviruses, with some additional structural features of β- and γ-herpesviruses. These results illustrate the structure of the PRV capsid and elucidate the underlying assembly mechanism at the molecular level. This knowledge may be useful for the development of oncolytic agents or specific therapeutics against this arm of the herpesvirus family.
リンク	Nat Commun / PubMed:35318331 / PubMed Central
手法	EM (単粒子)
解像度	3.31 - 6.79 Å
構造データ	EMDB-31591: Cryo-EM structure of PRV A-capsid 5-fold sub-particle 手法: EM (単粒子) / 解像度: 3.64 Å EMDB-31592: Cryo-EM structure of PRV A-capsid 3-fold sub-particle 手法: EM (単粒子) / 解像度: 3.5 Å EMDB-31593: Cryo-EM structure of PRV A-capsid 2-fold sub-particle 手法: EM (単粒子) / 解像度: 3.41 Å EMDB-31594: Cryo-EM structure of PRV C-capsid 5-fold sub-particle 手法: EM (単粒子) / 解像度: 3.31 Å EMDB-31608: Cryo-EM structure of PRV C-capsid 3-fold sub-particle 手法: EM (単粒子) / 解像度: 3.46 Å EMDB-31609: Cryo-EM structure of PRV C-capsid 2-fold sub-particle 手法: EM (単粒子) / 解像度: 3.43 Å EMDB-31610: Cryo-EM structure of PRV C-capsid portal vertex 手法: EM (単粒子) / 解像度: 6.79 Å 31611 7fj1 EMDB-31611, PDB-7fj1: Cryo-EM structure of pseudorabies virus C-capsid 手法: EM (単粒子) / 解像度: 4.43 Å 31612 7fj3 EMDB-31612, PDB-7fj3: Cryo-EM structure of PRV A-capid 手法: EM (単粒子) / 解像度: 4.53 Å EMDB-31616: Portal-based reconstruction of PRV C-capsid 手法: EM (単粒子) / 解像度: 4.72 Å
由来	suid alphaherpesvirus 1 (ヘルペスウイルス)
キーワード	VIRUS / Pseudorabies virus / C-capsid / Cryo-EM