タイトル | Solithromycin siderophore conjugates |
---|
ジャーナル・号・ページ | To Be Published |
---|
掲載日 | 2022年8月17日 (構造データの登録日) |
---|
著者 | Boyce JH / Pellegrino J / Lee DJ / Ecker AK / Seiple IB / Fraser JS |
---|
リンク | PubMedで検索 |
---|
手法 | EM (単粒子) |
---|
解像度 | 1.99 - 2.35 Å |
---|
構造データ | EMDB-27867, PDB-8e3l: E. coli 50S ribosome bound to D-linker solithromycin conjugate 手法: EM (単粒子) / 解像度: 2.35 Å EMDB-27868, PDB-8e3m: E. coli 50S ribosome bound to L-linker solithromycin conjugate 手法: EM (単粒子) / 解像度: 2.25 Å EMDB-27869, PDB-8e3o: E. coli 50S ribosome bound to solithromycin and VM1 手法: EM (単粒子) / 解像度: 1.99 Å |
---|
化合物 | ChemComp-UK3: (2~{R})-~{N}-[(2~{R})-6-azanyl-1-[[(2~{R})-1-[[(2~{R})-1-[[3-[1-[4-[(1~{S},2~{R},5~{S},7~{R},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-5-fluoranyl-9-methoxy-1,5,7,11,13-pentamethyl-4,6,12,16-tetrakis(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-15-yl]butyl]-1,2,3-triazol-4-yl]phenyl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-hexan-2-yl]-1-[(2~{R})-2-[[(2~{R})-2-[2-[[2,3-bis(oxidanyl)phenyl]carbonyl-[4-[[2,3-bis(oxidanyl)phenyl]carbonylamino]butyl]amino]ethanoylamino]-3-(1~{H}-indol-3-yl)propanoyl]amino]-3-oxidanyl-propanoyl]pyrrolidine-2-carboxamide
ChemComp-UIU: N-acetyl-L-tyrosyl-N-[(3M)-3-(1-{4-[(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-10-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}dodecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-1(4H)-yl]butyl}-1H-1,2,3-triazol-4-yl)phenyl]-L-methioninamide
ChemComp-EM1: (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a / ソリスロマイシン / 抗生剤*YM
|
---|
由来 | - escherichia coli (大腸菌)
- escherichia coli k-12 (大腸菌)
|
---|
キーワード | RIBOSOME / E. coli ribosome / solithromycin / siderophore conjugate / antibiotics |
---|