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-Structure paper
タイトル | Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine. |
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ジャーナル・号・ページ | Commun Biol, Vol. 6, Issue 1, Page 454, Year 2023 |
掲載日 | 2023年4月25日 |
![]() | John V Dzimianski / Julianna Han / Giuseppe A Sautto / Sara M O'Rourke / Joseph M Cruz / Spencer R Pierce / Jeffrey W Ecker / Michael A Carlock / Kaito A Nagashima / Jarrod J Mousa / Ted M Ross / Andrew B Ward / Rebecca M DuBois / ![]() |
PubMed 要旨 | Influenza virus poses an ongoing human health threat with pandemic potential. Due to mutations in circulating strains, formulating effective vaccines remains a challenge. The use of computationally ...Influenza virus poses an ongoing human health threat with pandemic potential. Due to mutations in circulating strains, formulating effective vaccines remains a challenge. The use of computationally optimized broadly reactive antigen (COBRA) hemagglutinin (HA) proteins is a promising vaccine strategy to protect against a wide range of current and future influenza viruses. Though effective in preclinical studies, the mechanistic basis driving the broad reactivity of COBRA proteins remains to be elucidated. Here, we report the crystal structure of the COBRA HA termed P1 and identify antigenic and glycosylation properties that contribute to its immunogenicity. We further report the cryo-EM structure of the P1-elicited broadly neutralizing antibody 1F8 bound to COBRA P1, revealing 1F8 to recognize an atypical receptor binding site epitope via an unexpected mode of binding. |
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手法 | EM (単粒子) / X線回折 |
解像度 | 3 - 3.1 Å |
構造データ | EMDB-26983, PDB-8ct6: ![]() PDB-7uyi: |
化合物 | ![]() ChemComp-NAG: ![]() ChemComp-HOH: |
由来 |
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![]() | VIRAL PROTEIN / hemagglutinin / virus entry / antigenic / Viral Protein/IMMUNE SYSTEM / influenza virus / COBRA / monoclonal antibody / IMMUNE SYSTEM / Viral Protein-IMMUNE SYSTEM complex |