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-Structure paper
タイトル | Chromatin localization of nucleophosmin organizes ribosome biogenesis. |
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ジャーナル・号・ページ | Mol Cell, Vol. 82, Issue 23, Page 4443-44457.e9, Year 2022 |
掲載日 | 2022年12月1日 |
著者 | Ilaria Ugolini / Silvija Bilokapic / Mylene Ferrolino / Josiah Teague / Yinxia Yan / Xuelin Zhou / Ashish Deshmukh / Michael White / Richard W Kriwacki / Mario Halic / |
PubMed 要旨 | Ribosome biogenesis takes place in the nucleolus, a nuclear membrane-less organelle. Although well studied, it remains unknown how nascent ribosomal subunits separate from the central chromatin ...Ribosome biogenesis takes place in the nucleolus, a nuclear membrane-less organelle. Although well studied, it remains unknown how nascent ribosomal subunits separate from the central chromatin compartment and move to the outer granular component, where maturation occurs. We find that the Schizosaccharomyces pombe nucleophosmin-like protein Fkbp39 localizes to rDNA sites encoding the 60S subunit rRNA, and this localization contributes to its specific association with nascent 60S subunits. Fkbp39 dissociates from chromatin to bind nascent 60S subunits, causing the latter to partition away from chromatin and from nascent 40S subunits through liquid-liquid phase separation. In vivo, Fkbp39 binding directs the translocation of nascent 60S subunits toward the nucleophosmin-rich granular component. This process increases the efficiency of 60S subunit assembly, facilitating the incorporation of 60S RNA domain III. Thus, chromatin localization determines the specificity of nucleophosmin in sorting nascent ribosomal subunits and coordinates their movement into specialized assembly compartments within the nucleolus. |
リンク | Mol Cell / PubMed:36423630 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 2.8 - 3.8 Å |
構造データ | EMDB-24395: Fkbp39 interacting nascent 60S subunit 1 EMDB-24396: Fkbp39 associated nascent 60S class 2 EMDB-24397: Fkbp39 associated nascent 60S class 3 EMDB-24398: Fkbp39 associated nascent 60S class 4 EMDB-24409: Ytm1 associated nascent 60S class 1B EMDB-24410: Ytm1 associated nascent 60S class 1A EMDB-24411: Ytm1 associated nascent 60S class 2 EMDB-24412: Ytm1 associated nascent 60S class 3 EMDB-24420: Ytm1 associated nascent 60S in fkbp39 deletion cells class 1A EMDB-24421: Ytm1 associated nascent 60S in fkbp39 deletion cells class 1B EMDB-24422: Ytm1 associated nascent 60S in fkbp39 deletion cells class 2 EMDB-24423: Ytm1 associated nascent 60S in fkbp39 deletion cells class 3 |
化合物 | ChemComp-ZN: |
由来 |
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キーワード | RIBOSOME / Nucleophosmin / ribosome biogenesis / fkbp / 60S ribosome |