EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants.
ジャーナル・号・ページ	Science, Vol. 373, Issue 6555, Page 642-648, Year 2021
掲載日	2021年8月6日
著者	Yongfei Cai / Jun Zhang / Tianshu Xiao / Christy L Lavine / Shaun Rawson / Hanqin Peng / Haisun Zhu / Krishna Anand / Pei Tong / Avneesh Gautam / Shen Lu / Sarah M Sterling / Richard M Walsh / Sophia Rits-Volloch / Jianming Lu / Duane R Wesemann / Wei Yang / Michael S Seaman / Bing Chen /
PubMed 要旨	Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating strains in the COVID-19 pandemic. We report here cryo-electron ...Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating strains in the COVID-19 pandemic. We report here cryo-electron microscopy structures of the full-length spike (S) trimers of the B.1.1.7 and B.1.351 variants, as well as their biochemical and antigenic properties. Amino acid substitutions in the B.1.1.7 protein increase both the accessibility of its receptor binding domain and the binding affinity for receptor angiotensin-converting enzyme 2 (ACE2). The enhanced receptor engagement may account for the increased transmissibility. The B.1.351 variant has evolved to reshape antigenic surfaces of the major neutralizing sites on the S protein, making it resistant to some potent neutralizing antibodies. These findings provide structural details on how SARS-CoV-2 has evolved to enhance viral fitness and immune evasion.
リンク	Science / PubMed:34168070 / PubMed Central
手法	EM (単粒子)
解像度	2.9 - 4.3 Å
構造データ	24121 7n1q EMDB-24121, PDB-7n1q: Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants 手法: EM (単粒子) / 解像度: 2.9 Å 24122 7n1t EMDB-24122, PDB-7n1t: Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants 手法: EM (単粒子) / 解像度: 3.11 Å 24123 7n1u EMDB-24123, PDB-7n1u: Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants 手法: EM (単粒子) / 解像度: 3.14 Å 24124 7n1v EMDB-24124, PDB-7n1v: Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants 手法: EM (単粒子) / 解像度: 3.21 Å 24125 7n1w EMDB-24125, PDB-7n1w: Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants 手法: EM (単粒子) / 解像度: 3.33 Å 24126 7n1x EMDB-24126, PDB-7n1x: Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants 手法: EM (単粒子) / 解像度: 4.0 Å 24127 7n1y EMDB-24127, PDB-7n1y: Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants 手法: EM (単粒子) / 解像度: 4.3 Å
化合物	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン
由来	severe acute respiratory syndrome coronavirus 2 (ウイルス)
キーワード	VIRAL PROTEIN