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-Structure paper
タイトル | The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes. |
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ジャーナル・号・ページ | Science, Vol. 374, Issue 6563, Page 52-57, Year 2021 |
掲載日 | 2021年9月30日 |
著者 | Ngoc-Han Tran / Stephen D Carter / Ann De Mazière / Avi Ashkenazi / Judith Klumperman / Peter Walter / Grant J Jensen / |
PubMed 要旨 | The signaling network of the unfolded protein response (UPR) adjusts the protein-folding capacity of the endoplasmic reticulum (ER) according to need. The most conserved UPR sensor, IRE1α, spans the ...The signaling network of the unfolded protein response (UPR) adjusts the protein-folding capacity of the endoplasmic reticulum (ER) according to need. The most conserved UPR sensor, IRE1α, spans the ER membrane and activates through oligomerization. IRE1α oligomers accumulate in dynamic foci. We determined the in situ structure of IRE1α foci by cryogenic correlated light and electron microscopy combined with electron cryo-tomography and complementary immuno–electron microscopy in mammalian cell lines. IRE1α foci localized to a network of narrow anastomosing ER tubes (diameter, ~28 nm) with complex branching. The lumen of the tubes contained protein filaments, which were likely composed of arrays of IRE1α lumenal domain dimers that were arranged in two intertwined, left-handed helices. This specialized ER subdomain may play a role in modulating IRE1α signaling. |
リンク | Science / PubMed:34591618 / PubMed Central |
手法 | EM (サブトモグラム平均) |
解像度 | 15.0 - 30.0 Å |
構造データ | EMDB-23058: EMDB-23060: |
由来 |
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