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-Structure paper
タイトル | Structural basis of temperature sensation by the TRP channel TRPV3. |
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ジャーナル・号・ページ | Nat Struct Mol Biol, Vol. 26, Issue 11, Page 994-998, Year 2019 |
掲載日 | 2019年10月21日 |
著者 | Appu K Singh / Luke L McGoldrick / Lusine Demirkhanyan / Merfilius Leslie / Eleonora Zakharian / Alexander I Sobolevsky / |
PubMed 要旨 | We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first ...We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo α-to-π transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains. |
リンク | Nat Struct Mol Biol / PubMed:31636415 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 4.07 - 5.18 Å |
構造データ | EMDB-20492, PDB-6pvl: EMDB-20493, PDB-6pvm: EMDB-20494, PDB-6pvn: EMDB-20495, PDB-6pvo: EMDB-20496, PDB-6pvp: EMDB-20497, PDB-6pvq: |
化合物 | ChemComp-NA: |
由来 |
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キーワード | TRANSPORT PROTEIN / Ion Channels / Membrane Protein / TRP Channels |