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-Structure paper
タイトル | Helical structure of the needle of the type III secretion system of Shigella flexneri. |
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ジャーナル・号・ページ | J Biol Chem, Vol. 278, Issue 19, Page 17103-17107, Year 2003 |
掲載日 | 2003年5月9日 |
![]() | Frank S Cordes / Kaoru Komoriya / Eric Larquet / Shixin Yang / Edward H Egelman / Ariel Blocker / Susan M Lea / ![]() |
PubMed 要旨 | Gram-negative bacteria commonly interact with animal and plant hosts using type III secretion systems (TTSSs) for translocation of proteins into eukaryotic cells during infection. 10 of the 25 TTSS- ...Gram-negative bacteria commonly interact with animal and plant hosts using type III secretion systems (TTSSs) for translocation of proteins into eukaryotic cells during infection. 10 of the 25 TTSS-encoding genes are homologous to components of the bacterial flagellar basal body, which the TTSS needle complex morphologically resembles. This indicates a common ancestry, although no TTSS sequence homologues for the genes encoding the flagellum are found. We here present an approximately 16-A structure of the central component, the needle, of the TTSS. Although the needle subunit is significantly smaller and shares no sequence homology with the flagellar hook and filament, it shares a common helical architecture ( approximately 5.6 subunits/turn, 24-A helical pitch). This common architecture implies that there will be further mechanistic analogies in the functioning of these two bacterial systems. |
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手法 | EM (らせん対称) |
解像度 | 16.0 Å |
構造データ | ![]() EMDB-1416: |
由来 |
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