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-Structure paper
タイトル | Direct visualization of the putative portal in the Kaposi's sarcoma-associated herpesvirus capsid by cryoelectron tomography. |
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ジャーナル・号・ページ | J Virol, Vol. 81, Issue 7, Page 3640-3644, Year 2007 |
掲載日 | 2007年1月10日 |
著者 | Binbin Deng / Christine M O'Connor / Dean H Kedes / Z Hong Zhou / |
PubMed 要旨 | Genetic and biochemical studies have suggested the existence of a bacteriophage-like, DNA-packaging/ejecting portal complex in herpesviruses capsids, but its arrangement remained unknown. Here, we ...Genetic and biochemical studies have suggested the existence of a bacteriophage-like, DNA-packaging/ejecting portal complex in herpesviruses capsids, but its arrangement remained unknown. Here, we report the first visualization of a unique vertex in the Kaposi's sarcoma-associated herpesvirus (KSHV) capsid by cryoelectron tomography, thus providing direct structural evidence for the existence of a portal complex in a gammaherpesvirus. This putative KSHV portal is an internally localized, umbilicated structure and lacks all of the external machineries characteristic of portals in DNA bacteriophages. |
リンク | J Virol / PubMed:17215290 / PubMed Central |
手法 | EM (サブトモグラム平均) |
解像度 | 40.0 Å |
構造データ | EMDB-1320: |