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-Structure paper
タイトル | Hexameric ring structure of human MCM10 DNA replication factor. |
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ジャーナル・号・ページ | EMBO Rep, Vol. 8, Issue 10, Page 925-930, Year 2007 |
掲載日 | 2007年9月7日 |
著者 | Andrei L Okorokov / Alastair Waugh / Julie Hodgkinson / Andal Murthy / Hye Kyung Hong / Elisabetta Leo / Michael B Sherman / Kai Stoeber / Elena V Orlova / Gareth H Williams / |
PubMed 要旨 | The DNA replication factor minichromosome maintenance 10 (MCM10) is a conserved, abundant nuclear protein crucial for origin firing. During the transition from pre-replicative complexes to pre- ...The DNA replication factor minichromosome maintenance 10 (MCM10) is a conserved, abundant nuclear protein crucial for origin firing. During the transition from pre-replicative complexes to pre-initiation complexes, MCM10 recruitment to replication origins is required to provide a physical link between the MCM2-7 complex DNA helicase and DNA polymerases. Here, we report the molecular structure of human MCM10 as determined by electron microscopy and single-particle analysis. The MCM10 molecule is a ring-shaped hexamer with large central and smaller lateral channels and a system of inner chambers. This structure, together with biochemical data, suggests that this important protein uses its architecture to provide a docking module for assembly of the molecular machinery required for eukaryotic DNA replication. |
リンク | EMBO Rep / PubMed:17823614 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 16.0 Å |
構造データ | EMDB-1254: |
由来 |
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