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-Structure paper
タイトル | Molecular structure of human geminin. |
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ジャーナル・号・ページ | Nat Struct Mol Biol, Vol. 11, Issue 10, Page 1021-1022, Year 2004 |
掲載日 | 2004年9月19日 |
著者 | Andrei L Okorokov / Elena V Orlova / Sarah R Kingsbury / Claire Bagneris / Ulrich Gohlke / Gareth H Williams / Kai Stoeber / |
PubMed 要旨 | The origin licensing repressor geminin is a unique bifunctional protein providing a molecular link between cellular proliferation, differentiation and genomic stability. Here we report the first ...The origin licensing repressor geminin is a unique bifunctional protein providing a molecular link between cellular proliferation, differentiation and genomic stability. Here we report the first molecular structure of human geminin, determined by EM and image processing at a resolution of 17.5 A. The geminin molecule is a tetramer formed by two dimers with monomers interacting via coiled-coil domains. The unusual structural organization of geminin provides molecular insight into its bifunctional nature. |
リンク | Nat Struct Mol Biol / PubMed:15378034 |
手法 | EM (単粒子) |
解像度 | 18.0 Å |
構造データ | EMDB-1190: |
由来 |
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