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-Structure paper
タイトル | Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. |
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ジャーナル・号・ページ | Neuron, Vol. 41, Issue 4, Page 513-519, Year 2004 |
掲載日 | 2004年2月19日 |
著者 | Leo A Kim / Johannes Furst / David Gutierrez / Margaret H Butler / Shuhua Xu / Steve A N Goldstein / Nikolaus Grigorieff / |
PubMed 要旨 | Regulatory KChIP2 subunits assemble with pore-forming Kv4.2 subunits in 4:4 complexes to produce native voltage-gated potassium (Kv) channels like cardiac I(to) and neuronal I(A) subtypes. Here, ...Regulatory KChIP2 subunits assemble with pore-forming Kv4.2 subunits in 4:4 complexes to produce native voltage-gated potassium (Kv) channels like cardiac I(to) and neuronal I(A) subtypes. Here, negative stain electron microscopy (EM) and single particle averaging reveal KChIP2 to create a novel approximately 35 x 115 x 115 Angstrom, intracellular fenestrated rotunda: four peripheral columns that extend down from the membrane-embedded portion of the channel to enclose the Kv4.2 "hanging gondola" (a platform held beneath the transmembrane conduction pore by four internal columns). To reach the pore from the cytosol, ions traverse one of four external fenestrae to enter the rotundal vestibule and then cross one of four internal windows in the gondola. |
リンク | Neuron / PubMed:14980201 |
手法 | EM (単粒子) |
解像度 | 21.0 Å |
構造データ | EMDB-1074: |
由来 |
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