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-Structure paper
タイトル | Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins. |
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ジャーナル・号・ページ | Nat Neurosci, Vol. 23, Issue 2, Page 172-175, Year 2020 |
掲載日 | 2020年1月6日 |
著者 | Simon Erlendsson / Dustin R Morado / Harrison B Cullen / Cedric Feschotte / Jason D Shepherd / John A G Briggs / |
PubMed 要旨 | Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high- ...Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication. |
リンク | Nat Neurosci / PubMed:31907439 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 2.75 - 3.9 Å |
構造データ | EMDB-10423, PDB-6tap: EMDB-10424, PDB-6taq: EMDB-10425, PDB-6tar: EMDB-10426, PDB-6tas: EMDB-10427, PDB-6tat: EMDB-10428, PDB-6tau: |
化合物 | ChemComp-ZN: |
由来 |
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キーワード | VIRUS LIKE PARTICLE / dArc / Gag / Virus / VLP |