EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
ジャーナル・号・ページ	Bioorg. Med. Chem., Vol. 22, Page 4135-, Year 2014
掲載日	2014年4月2日 (構造データの登録日)
著者	Casale, E. / Amboldi, N. / Brasca, M.G. / Caronni, D. / Colombo, N. / Dalvit, C. / Felder, E.R. / Fogliatto, G. / Galvani, A. / Isacchi, A. ...Casale, E. / Amboldi, N. / Brasca, M.G. / Caronni, D. / Colombo, N. / Dalvit, C. / Felder, E.R. / Fogliatto, G. / Galvani, A. / Isacchi, A. / Polucci, P. / Riceputi, L. / Sola, F. / Visco, C. / Zuccotto, F. / Casuscelli, F.
リンク	Bioorg. Med. Chem. / PubMed:24980703
手法	X線回折
解像度	1.8 - 2.31 Å
構造データ	PDB-4cwf: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4cwn: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-4cwo: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å PDB-4cwp: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-4cwq: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4cwr: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-4cws: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-4cwt: Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å
化合物	ChemComp-H05: 5-propyl[1,2,4]triazolo[1,5-c]quinazolin-2-amine ChemComp-HOH: WATER / 水 ChemComp-6LV: 5-(3,5-dimethoxybenzyl)[1,2,4]triazolo[1,5-c]quinazolin-2-amine ChemComp-T62: 5-(2-amino-[1,2,4]triazolo[1,5-c]quinazolin-5-ylmethyl)-benzene-1,3-diol ChemComp-TV2: 5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazolin-2-amine ChemComp-W2D: 2-amino-5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazoline-8-sulfonamide ChemComp-HAJ: 5-(1,3-benzodioxol-5-ylmethyl)-10-fluoro[1,2,4]triazolo[1,5-c]quinazolin-2-amine ChemComp-G3R: 2-{[2-amino-5-(1,3-benzodioxol-5-ylmethyl)[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino}ethanol ChemComp-IK9: 2-{[(2Z)-5-(1,3-benzodioxol-5-ylmethyl)-8-fluoro-2-imino-2,3-dihydro[1,2,4]triazolo[1,5-c]quinazolin-10-yl]amino}ethanol
由来	homo sapiens (ヒト)
キーワード	CHAPERONE (シャペロン)