EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-Based Design of Novel Chk1 Inhibitors: Insights Into Hydrogen Bonding and Protein-Ligand Affinity.
ジャーナル・号・ページ	J. Med. Chem., Vol. 48, Page 4332-, Year 2005
掲載日	2005年4月29日 (構造データの登録日)
著者	Foloppe, N. / Fisher, L.M. / Howes, R. / Kierstan, P. / Potter, A. / Robertson, A.G.S. / Surgenor, A.E.
リンク	J. Med. Chem. / PubMed:15974586
手法	X線回折
解像度	2 - 2.8 Å
構造データ	PDB-2br1: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2brb: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2brg: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2brh: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-2brm: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2brn: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-2bro: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å
化合物	ChemComp-PFP: 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL ChemComp-SO4: SULFATE ION / 硫酸ジアニオン / 硫酸塩 ChemComp-HOH: WATER / 水 ChemComp-PFQ: 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL ChemComp-DFY: (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC ChemComp-DFW: N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE ChemComp-DFZ: 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE ChemComp-DF1: (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL ChemComp-DF2: (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE (転移酵素) / DRUG DESIGN (医薬品設計) / FURANOPYRIMIDINE / MOLECULAR RECOGNITION (分子認識) / ONCOLOGY (腫瘍学) / PYRROLOPYRIMIDINE / KINASE (キナーゼ) / ATP-BINDING / CELL CYCLE (細胞周期) / DNA DAMAGE (DNA修復) / NUCLEAR PROTEIN / PHOSPHORYLATION (リン酸化) / POLYMORPHISM / SERINE/THREONINE-PROTEIN KINASE