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TitleMonoclonal antibodies targeting the FimH adhesin protect against uropathogenic UTI.
Journal, issue, pagesSci Adv, Vol. 11, Issue 25, Page eadw0698, Year 2025
Publish dateJun 20, 2025
AuthorsEdward D B Lopatto / Jesús M Santiago-Borges / Denise A Sanick / Sameer Kumar Malladi / Philippe N Azimzadeh / Morgan W Timm / Isabella F Fox / Aaron J Schmitz / Jackson S Turner / Shaza M Sayed Ahmed / Lillian Ortinau / Nathaniel C Gualberto / Jerome S Pinkner / Karen W Dodson / Ali H Ellebedy / Andrew L Kau / Scott J Hultgren /
PubMed AbstractAs antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the health care system, increasing the need for alternative ...As antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the health care system, increasing the need for alternative antibiotic-sparing treatments. Most UTIs are caused by uropathogenic (UPEC), whereas causes a large portion of non-UPEC UTIs. Both bacteria express type 1 pili tipped with the mannose-binding FimH adhesin critical for UTI pathogenesis. We generated and biochemically characterized 33 murine monoclonal antibodies (mAbs) to FimH. Three mAbs protected mice from UTI. Mechanistically, we show that this protection is Fc independent and mediated by the ability of these mAbs to sterically block FimH function by recognizing a high-affinity FimH conformation. Our data reveal that FimH mAbs hold promise as an antibiotic-sparing treatment strategy.
External linksSci Adv / PubMed:40540557 / PubMed Central
MethodsEM (single particle)
Resolution3.17 - 3.8 Å
Structure data

45456

9ccs

EMDB-45456, PDB-9ccs:
CryoEM Structure of Escherichia coli FimCH in complex with 2H04 Fab
Method: EM (single particle) / Resolution: 3.17 Å

45457

9cct

EMDB-45457, PDB-9cct:
CryoEM Structure of Escherichia coli FimCH in complex with B7 Fab
Method: EM (single particle) / Resolution: 3.46 Å

45458

9ccu

EMDB-45458, PDB-9ccu:
CryoEM Structure of Escherichia coli FimCH in complex with F7 Fab
Method: EM (single particle) / Resolution: 3.8 Å

45460

9ccw

EMDB-45460, PDB-9ccw:
CryoEM Structure of Escherichia coli FimCH in complex with 2C07 Fab
Method: EM (single particle) / Resolution: 3.69 Å

Source
  • Escherichia coli (E. coli)
  • mus musculus (house mouse)
  • escherichia coli uti89 (bacteria)
KeywordsCELL ADHESION / Adhesin / Inhibitor / complex / Fab / Chaperone / Usher / Pili

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