+Search query
-Structure paper
Title | Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 67, Page 11197-11208, Year 2024 |
Publish date | Mar 25, 2024 (structure data deposition date) |
Authors | Yamada, T. / Mihara, K. / Ueda, T. / Yamauchi, D. / Shimizu, M. / Ando, A. / Mayumi, K. / Nakata, Z. / Mikamiyama, H. |
External links | J. Med. Chem. / PubMed:38950284 |
Methods | X-ray diffraction |
Resolution | 2.26 - 2.34 Å |
Structure data | PDB-8ytd: PDB-8yte: |
Chemicals | ChemComp-EDO: ChemComp-HOH: ChemComp-GM1: |
Source |
|
Keywords | TRANSFERASE / cyclic peptide |