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-Structure paper
Title | Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 98, Page 129575-129575, Year 2023 |
Publish date | Sep 14, 2023 (structure data deposition date) |
Authors | Kageji, H. / Momose, T. / Nagamoto, Y. / Togashi, N. / Yasumatsu, I. / Nishikawa, Y. / Kihara, K. / Hiramoto, K. / Minami, M. / Kasanuki, N. ...Kageji, H. / Momose, T. / Nagamoto, Y. / Togashi, N. / Yasumatsu, I. / Nishikawa, Y. / Kihara, K. / Hiramoto, K. / Minami, M. / Kasanuki, N. / Isoyama, T. / Naito, H. |
External links | Bioorg. Med. Chem. Lett. / PubMed:38065292 |
Methods | X-ray diffraction |
Resolution | 2.55 Å |
Structure data | PDB-8wd4: |
Chemicals | ChemComp-W7W: ChemComp-CL: ChemComp-HOH: |
Source |
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Keywords | ONCOPROTEIN / EGFR / C797S / Drug Discovery |