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-Structure paper
Title | Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 121, Page e2314101120-e2314101120, Year 2024 |
Publish date | Nov 3, 2023 (structure data deposition date) |
Authors | Phelps, G.A. / Cheramie, M.N. / Fernando, D.M. / Selchow, P. / Meyer, C.J. / Waidyarachchi, S.L. / Dharuman, S. / Liu, J. / Meuli, M. / Molin, M.D. ...Phelps, G.A. / Cheramie, M.N. / Fernando, D.M. / Selchow, P. / Meyer, C.J. / Waidyarachchi, S.L. / Dharuman, S. / Liu, J. / Meuli, M. / Molin, M.D. / Killam, B.Y. / Murphy, P.A. / Reeve, S.M. / Wilt, L.A. / Anderson, S.M. / Yang, L. / Lee, R.B. / Temrikar, Z.H. / Lukka, P.B. / Meibohm, B. / Polikanov, Y.S. / Hobbie, S.N. / Bottger, E.C. / Sander, P. / Lee, R.E. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:38165935 |
Methods | X-ray diffraction |
Resolution | 2.6 - 2.75 Å |
Structure data | PDB-8uvr: PDB-8uvs: |
Chemicals | ChemComp-MG: ChemComp-K: ChemComp-ZN: ChemComp-SCM: ChemComp-SF4: ChemComp-HOH:
ChemComp-Y7K: |
Source |
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Keywords | RIBOSOME/INHIBITOR / ANTIBIOTIC / Spectinomycin; aminomethyl spectinomycin; antibiotic; 70S ribosome; X-ray structure; inhibition of translation; infectious diseases; antimicrobial drug discovery; semisynthetic chemistry; drug development / RIBOSOME / RIBOSOME-INHIBITOR / ANTIBIOTIC complex / RIBOSOME-INHIBITOR complex |