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Structure paper

TitleAn RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting
Journal, issue, pagesNat Commun, Year 2025
Publish dateOct 26, 2023 (structure data deposition date)
AuthorsKimbrough EM / Nguyen HA / Li H / Bailey NA / Ning W / Mattingly JM / Gamper H / Hou YM / Gonzalez RL / Dunham CM
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.9 - 4.0 Å
Structure data

42495

8urm

EMDB-42495, PDB-8urm:
E. coli 70S ribosome with unmodified tRNAPro(GGG) bound to slippery P-site CCC-C codon and tRNAVal(UAC) in the A site
Method: EM (single particle) / Resolution: 3.0 Å

42541

8utj

EMDB-42541, PDB-8utj:
E. coli 70S ribosome with unmodified lys-tRNAPro(GGG) bound to slippery P-site CCC-C codon in the 0 frame
Method: EM (single particle) / Resolution: 3.5 Å

42714

8ux8

EMDB-42714, PDB-8ux8:
E. coli 70S ribosome with unmodified Lys-tRNAPro(GGG) bound to slippery P-site CCC-C codon in the +1 mRNA reading frame
Method: EM (single particle) / Resolution: 3.6 Å

42721

8uxb

EMDB-42721, PDB-8uxb:
E. coli 70S ribosome with unmodified P/E-tRNAPro(GGG) bound to slippery P-site CCC-C codon
Method: EM (single particle) / Resolution: 2.9 Å

42832

8uz3

EMDB-42832, PDB-8uz3:
E. coli 70S ribosome with unmodified e*/E-tRNAPro(GGG) bound to slippery P-site CCC-C codon
Method: EM (single particle) / Resolution: 3.2 Å

42840

8uzg

EMDB-42840, PDB-8uzg:
E. coli 70S ribosome with unmodified e*/E-tRNAPro(GGG) bound to slippery P-site CCC-C codon
Method: EM (single particle) / Resolution: 3.7 Å

42852

8v03

EMDB-42852, PDB-8v03:
E. coli 70S ribosome with unmodified P/E-tRNAPro(GGG) bound to slippery P-site CCC-C codon
Method: EM (single particle) / Resolution: 4.0 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-LYS:
LYSINE

Source
  • escherichia coli (E. coli)
KeywordsRIBOSOME / 70S ribosome / tRNA / mRNA / frameshift

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