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TitleDynamics underlie the drug recognition mechanism by the efflux transporter EmrE.
Journal, issue, pagesNat Commun, Vol. 15, Page 4537-4537, Year 2024
Publish dateOct 20, 2023 (structure data deposition date)
AuthorsLi, J. / Her, A.S. / Besch, A. / Ramirez-Cordero, B. / Crames, M. / Banigan, J.R. / Mueller, C. / Marsiglia, W.M. / Zhang, Y. / Traaseth, N.J.
External linksNat Commun / PubMed:38806470
MethodsNMR (solution) / NMR (solid-state)
Structure data

PDB-8uoz:
EmrE structure in the TPP-bound state (WT/E14Q heterodimer)
Method: SOLUTION NMR / SOLID-STATE NMR

PDB-8uwu:
EmrE structure in the proton-bound state (WT/L51I heterodimer)
Method: SOLUTION NMR / SOLID-STATE NMR

Chemicals

ChemComp-P4P:
TETRAPHENYLPHOSPHONIUM

Source
  • escherichia coli (E. coli)
KeywordsMEMBRANE PROTEIN / Multidrug transporter / efflux pump

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