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Title | The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N -(6-methylpyrazolo[1,5- a ]pyrimidin-3-yl)imidazo[1,2- a ]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 4676-4690, Year 2024 |
Publish date | Sep 26, 2023 (structure data deposition date) |
Authors | Evans, R. / Bolduc, P.N. / Pfaffenbach, M. / Gao, F. / May-Dracka, T. / Fang, T. / Hopkins, B.T. / Chodaparambil, J.V. / Henry, K.L. / Li, P. ...Evans, R. / Bolduc, P.N. / Pfaffenbach, M. / Gao, F. / May-Dracka, T. / Fang, T. / Hopkins, B.T. / Chodaparambil, J.V. / Henry, K.L. / Li, P. / Metrick, C. / Nelson, A. / Trapa, P. / Thomas, A. / Burkly, L. / Peterson, E.A. |
External links | J. Med. Chem. / PubMed:38467640 |
Methods | X-ray diffraction |
Resolution | 1.8 - 1.85 Å |
Structure data | PDB-8ucb: PDB-8ucc: |
Chemicals |
ChemComp-X1T: ChemComp-HOH:
ChemComp-WFQ: |
Source |
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Keywords | TRANSFERASE/INHIBITOR / kinase / TRANSFERASE / TRANSFERASE-INHIBITOR complex |