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Title | Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. |
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Journal, issue, pages | Nature, Vol. 629, Page 919-926, Year 2024 |
Publish date | Jun 28, 2023 (structure data deposition date) |
Authors | Holderfield, M. / Lee, B.J. / Jiang, J. / Tomlinson, A. / Seamon, K.J. / Mira, A. / Patrucco, E. / Goodhart, G. / Dilly, J. / Gindin, Y. ...Holderfield, M. / Lee, B.J. / Jiang, J. / Tomlinson, A. / Seamon, K.J. / Mira, A. / Patrucco, E. / Goodhart, G. / Dilly, J. / Gindin, Y. / Dinglasan, N. / Wang, Y. / Lai, L.P. / Cai, S. / Jiang, L. / Nasholm, N. / Shifrin, N. / Blaj, C. / Shah, H. / Evans, J.W. / Montazer, N. / Lai, O. / Shi, J. / Ahler, E. / Quintana, E. / Chang, S. / Salvador, A. / Marquez, A. / Cregg, J. / Liu, Y. / Milin, A. / Chen, A. / Ziv, T.B. / Parsons, D. / Knox, J.E. / Klomp, J.E. / Roth, J. / Rees, M. / Ronan, M. / Cuevas-Navarro, A. / Hu, F. / Lito, P. / Santamaria, D. / Aguirre, A.J. / Waters, A.M. / Der, C.J. / Ambrogio, C. / Wang, Z. / Gill, A.L. / Koltun, E.S. / Smith, J.A.M. / Wildes, D. / Singh, M. |
External links | Nature / PubMed:38589574 |
Methods | X-ray diffraction |
Resolution | 1.2 - 1.88 Å |
Structure data | PDB-8tbf: PDB-8tbg: PDB-8tbh: PDB-8tbi: PDB-8tbj: PDB-8tbk: PDB-8tbl: PDB-8tbm: PDB-8tbn: |
Chemicals | ChemComp-GNP: ChemComp-MG: ChemComp-EDO:
ChemComp-ZNI: ChemComp-HOH: ChemComp-GOL: |
Source |
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Keywords | HYDROLASE/INHIBITOR / inhibitor / complex / small GTPase / cancer / tricomplex / HYDROLASE-INHIBITOR complex |