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TitleDirected evolution of a highly efficient TNA polymerase achieved by homologous recombination
Journal, issue, pagesNat Catal, Year 2024
Publish dateJun 7, 2023 (structure data deposition date)
AuthorsMaola, V.A. / Yik, E.J. / Hajjar, M. / Lee, J.J. / Holguin, M.J. / Quijano, R.N. / Nguyen, K.K. / Ho, K.L. / Medina, J.V. / Chim, N. / Chaput, J.C.
External linksNat Catal / Search PubMed
MethodsX-ray diffraction
Resolution2.73 Å
Structure data

PDB-8t3x:
TNA polymerase, closed ternary
Method: X-RAY DIFFRACTION / Resolution: 2.73 Å

Chemicals

ChemComp-9O7:
[(3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate

ChemComp-MG:
Unknown entry

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • thermococcus kodakarensis (archaea)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / DNA polymerase / transferase / transferase-DNA complex

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