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-Structure paper
Title | Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 5093-5108, Year 2024 |
Publish date | Feb 6, 2024 (structure data deposition date) |
Authors | Thoma, G. / Miltz, W. / Srinivas, H. / Penno, C.A. / Kiffe, M. / Gajewska, M. / Klein, K. / Evans, A. / Beerli, C. / Rohn, T.A. |
External links | J. Med. Chem. / PubMed:38476002 |
Methods | X-ray diffraction |
Resolution | 1.85 - 2.9 Å |
Structure data | PDB-8rx3: PDB-8rx7: PDB-8rx9: |
Chemicals | ChemComp-ZN: ChemComp-ACT: ChemComp-YB: ChemComp-IMD: PDB-1h3t: ChemComp-HOH:
PDB-1h3s: 4-Alkoxy-2,6-diaminopyrimidine inhibitor bound to T160 phosphorylated CDK2/Cyclin A PDB-1h3u: |
Source |
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Keywords | HYDROLASE / LTA4H / Inhibitor |