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Structure paper

TitleBridging the maytansine and vinca sites: Cryptophycins target beta-tubulin's T5-loop.
Journal, issue, pagesJ. Biol. Chem., Vol. 300, Page 107363-107363, Year 2024
Publish dateNov 21, 2023 (structure data deposition date)
AuthorsAbel, A.C. / Muhlethaler, T. / Dessin, C. / Schachtsiek, T. / Sammet, B. / Sharpe, T. / Steinmetz, M.O. / Sewald, N. / Prota, A.E.
External linksJ. Biol. Chem. / PubMed:38735475
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-8r67:
tubulin-cryptophycin complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-IMD:
IMIDAZOLE

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GOL:
GLYCEROL


ChemComp, No image

ChemComp-Y74:
Unknown entry

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • bos taurus (cattle)
KeywordsCELL CYCLE / TUBULIN FOLD / CYTOSKELETON / MICROTUBULE

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