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-Structure paper
Title | Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 16410-16425, Year 2023 |
Publish date | Sep 29, 2023 (structure data deposition date) |
Authors | Thoma, G. / Markert, C. / Lueoend, R. / Miltz, W. / Spanka, C. / Bollbuck, B. / Wolf, R.M. / Srinivas, H. / Penno, C.A. / Kiffe, M. ...Thoma, G. / Markert, C. / Lueoend, R. / Miltz, W. / Spanka, C. / Bollbuck, B. / Wolf, R.M. / Srinivas, H. / Penno, C.A. / Kiffe, M. / Gajewska, M. / Bednarczyk, D. / Wieczorek, G. / Evans, A. / Beerli, C. / Rohn, T.A. |
External links | J. Med. Chem. / PubMed:38015154 |
Methods | X-ray diffraction |
Resolution | 1.6 - 2.35 Å |
Structure data | PDB-8qow: PDB-8qpn: PDB-8qq4: |
Chemicals | ChemComp-ZN: ChemComp-ACT: ChemComp-YB: ChemComp-IMD: ChemComp-WID: ChemComp-HOH: ChemComp-WSL: ChemComp-WEE: |
Source |
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Keywords | HYDROLASE / LTA4H / Inhibitors |