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Structure paper

TitleThe Molecular Basis of Human ALKBH3 Mediated RNA N 1 -methyladenosine (m 1 A) Demethylation.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 63, Page e202313900-e202313900, Year 2024
Publish dateJun 6, 2023 (structure data deposition date)
AuthorsZhang, L. / Duan, H.C. / Paduch, M. / Hu, J. / Zhang, C. / Mu, Y. / Lin, H. / He, C. / Kossiakoff, A.A. / Jia, G.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:38158383
MethodsX-ray diffraction
Resolution2.69 - 3.66 Å
Structure data

PDB-8jnk:
Crystal structure of human ALKBH3 bound to ssDNA through active site crosslink
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

PDB-8jnr:
Crystal structure of human ALKBH3 bound to 3mC containing ssDNA through distal crosslink
Method: X-RAY DIFFRACTION / Resolution: 3.66 Å

Chemicals

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-MN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ME6:
[(2R,3S,5R)-5-(4-azanyl-3-methyl-2-oxo-pyrimidin-3-ium-1-yl)-3-hydroxy-oxolan-2-yl]methyl dihydrogen phosphate

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / RNA m1A demethylase / DNA BINDING PROTEIN/DNA / DNA BINDING PROTEIN-DNA COMPLEX

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