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-Structure paper
Title | A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity. |
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Journal, issue, pages | Angew. Chem. Int. Ed. Engl., Vol. 63, Page e202410438-e202410438, Year 2024 |
Publish date | Feb 24, 2023 (structure data deposition date) |
Authors | Wu, Y. / Chen, Y. / Corner, T.P. / Nakashima, Y. / Salah, E. / Li, Z. / Zhang, L. / Yang, L. / Tumber, A. / Sun, Z. ...Wu, Y. / Chen, Y. / Corner, T.P. / Nakashima, Y. / Salah, E. / Li, Z. / Zhang, L. / Yang, L. / Tumber, A. / Sun, Z. / Wen, Y. / Zhong, A. / Yang, F. / Li, X. / Zhang, Z. / Schofield, C.J. / Zhang, X. |
External links | Angew. Chem. Int. Ed. Engl. / PubMed:38923188 |
Methods | X-ray diffraction |
Resolution | 2.04 - 2.22 Å |
Structure data | PDB-8ihz: PDB-8ii0: |
Chemicals | ChemComp-SO4: ChemComp-ZN:
ChemComp-P1X: ChemComp-HOH:
ChemComp-P5I: ChemComp-GOL: |
Source |
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Keywords | OXIDOREDUCTASE / factor-inhibiting hypoxia-inducible factor / FIH / 2OG dependent dioxygenase |