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Title | Discovery of Quinazoline-2,4(1 H ,3 H )-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 14095-14115, Year 2023 |
Publish date | Nov 7, 2022 (structure data deposition date) |
Authors | Zhou, J. / Du, T. / Wang, X. / Yao, H. / Deng, J. / Li, Y. / Chen, X. / Sheng, L. / Ji, M. / Xu, B. |
External links | J. Med. Chem. / PubMed:37843892 |
Methods | X-ray diffraction |
Resolution | 2.1 - 3.05 Å |
Structure data | PDB-8he7: PDB-8he8: |
Chemicals | ChemComp-1WI: ChemComp-SO4: ChemComp-HOH: ChemComp-GOL: |
Source |
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Keywords | TRANSFERASE / DNA ADP-ribosyltransferase 1 / PARP1 / Inhibitor / PARP-2 / DNA ADP-ribosyltransferase |