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TitlePGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.
Journal, issue, pagesAcs Cent. Sci., Vol. 9, Page 1388-1399, Year 2023
Publish dateOct 11, 2022 (structure data deposition date)
AuthorsIshizuka, S. / van Dijk, J.H.M. / Kawakita, T. / Miyamoto, Y. / Maeda, Y. / Goto, M. / Le Calvez, G. / Groot, L.M. / Witte, M.D. / Minnaard, A.J. ...Ishizuka, S. / van Dijk, J.H.M. / Kawakita, T. / Miyamoto, Y. / Maeda, Y. / Goto, M. / Le Calvez, G. / Groot, L.M. / Witte, M.D. / Minnaard, A.J. / van der Marel, G.A. / Ato, M. / Nagae, M. / Codee, J.D.C. / Yamasaki, S.
External linksAcs Cent. Sci. / PubMed:37521780
MethodsX-ray diffraction
Resolution2.4 - 2.6 Å
Structure data

PDB-8h4v:
Mincle CRD complex with PGL trisaccharide
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-8hb5:
Crystal structure of Mincle in complex with HD-275
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-L6N:
(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol

ChemComp-HOH:
WATER

Source
  • bos taurus (cattle)
KeywordsSUGAR BINDING PROTEIN / Immune receptor / Innate immunity / C-type lectin receptor / Mycobacterium leprae / IMMUNE SYSTEM / C-type lectin receptors

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