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-Structure paper
Title | Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin. |
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Journal, issue, pages | Protein Sci., Vol. 33, Page e5110-e5110, Year 2024 |
Publish date | Feb 3, 2023 (structure data deposition date) |
![]() | Mahoney, M.W. / Helander, J. / Kooner, A.S. / Norman, M. / Damalanka, V.C. / De Bona, P. / Kasperkiewicz, P. / Rut, W. / Poreba, M. / Kashipathy, M.M. ...Mahoney, M.W. / Helander, J. / Kooner, A.S. / Norman, M. / Damalanka, V.C. / De Bona, P. / Kasperkiewicz, P. / Rut, W. / Poreba, M. / Kashipathy, M.M. / Battaile, K.P. / Lovell, S. / O'Donoghue, A.J. / Craik, C.S. / Drag, M. / Janetka, J.W. |
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Methods | X-ray diffraction |
Resolution | 1.35 Å |
Structure data | ![]() PDB-8g1v: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-CL: ![]() ChemComp-GOL: ![]()
ChemComp-YIL: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / MATRIPTASE / INHIBITOR COMPLEX / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |