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Title | Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. |
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Journal, issue, pages | Plos Pathog., Vol. 18, Page e1011065-e1011065, Year 2022 |
Publish date | May 20, 2022 (structure data deposition date) |
Authors | van Vliet, V.J.E. / Huynh, N. / Pala, J. / Patel, A. / Singer, A. / Slater, C. / Chung, J. / van Huizen, M. / Teyra, J. / Miersch, S. ...van Vliet, V.J.E. / Huynh, N. / Pala, J. / Patel, A. / Singer, A. / Slater, C. / Chung, J. / van Huizen, M. / Teyra, J. / Miersch, S. / Luu, G.K. / Ye, W. / Sharma, N. / Ganaie, S.S. / Russell, R. / Chen, C. / Maynard, M. / Amarasinghe, G.K. / Mark, B.L. / Kikkert, M. / Sidhu, S.S. |
External links | Plos Pathog. / PubMed:36548304 |
Methods | X-ray diffraction |
Resolution | 3.5 Å |
Structure data | PDB-8cx9: |
Chemicals | ChemComp-ZN: ChemComp-BR: ChemComp-NA: ChemComp-CL: |
Source |
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Keywords | VIRAL PROTEIN/SIGNALING PROTEIN / inhibitor complex / allosteric inhibition / VIRAL PROTEIN / VIRAL PROTEIN-SIGNALING PROTEIN complex |