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Title | Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii . |
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Journal, issue, pages | Antibiotics, Vol. 12, Year 2023 |
Publish date | May 17, 2022 (structure data deposition date) |
![]() | Introvigne, M.L. / Beardsley, T.J. / Fernando, M.C. / Leonard, D.A. / Wallar, B.J. / Rudin, S.D. / Taracila, M.A. / Rather, P.N. / Colquhoun, J.M. / Song, S. ...Introvigne, M.L. / Beardsley, T.J. / Fernando, M.C. / Leonard, D.A. / Wallar, B.J. / Rudin, S.D. / Taracila, M.A. / Rather, P.N. / Colquhoun, J.M. / Song, S. / Fini, F. / Hujer, K.M. / Hujer, A.M. / Prati, F. / Powers, R.A. / Bonomo, R.A. / Caselli, E. |
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Methods | X-ray diffraction |
Resolution | 1.47 - 2.01 Å |
Structure data | ![]() PDB-8cul: ![]() PDB-8cum: ![]() PDB-8cuo: ![]() PDB-8cup: ![]() PDB-8cuq: |
Chemicals | ![]() ChemComp-0N3: ![]() ChemComp-HOH: ![]() ChemComp-OZ0: ![]() ChemComp-SO4: ![]() ChemComp-OZ9: ![]() ChemComp-OZF: ![]() ChemComp-OZO: |
Source |
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![]() | Hydrolase/Inhibitor / carbapenemase / BATSI / inhibitor / HYDROLASE / Hydrolase-Inhibitor complex / Cephalasporinase |