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-Structure paper
Title | 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor. |
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Journal, issue, pages | Acta Crystallogr D Struct Biol, Vol. 79, Page 721-734, Year 2023 |
Publish date | Mar 1, 2023 (structure data deposition date) |
Authors | Martinez, M. / Batista, F.A. / Maurel, M. / Bouillon, A. / Ortega Varga, L. / Wehenkel, A.M. / Le Chevalier-Sontag, L. / Blondel, A. / Haouz, A. / Hernandez, J.F. ...Martinez, M. / Batista, F.A. / Maurel, M. / Bouillon, A. / Ortega Varga, L. / Wehenkel, A.M. / Le Chevalier-Sontag, L. / Blondel, A. / Haouz, A. / Hernandez, J.F. / Alzari, P.M. / Barale, J.C. |
External links | Acta Crystallogr D Struct Biol / PubMed:37428845 |
Methods | X-ray diffraction |
Resolution | 1.438 - 3.251 Å |
Structure data | PDB-8coy: PDB-8coz: PDB-8cp0: |
Chemicals | ChemComp-NAG: ChemComp-CA: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Plasmodium / serine protease / drug target / malaria / pseudo-peptide inhibitor |