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-Structure paper
Title | Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis. |
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Journal, issue, pages | Acs Infect Dis., Vol. 10, Page 1935-1948, Year 2024 |
Publish date | Jan 26, 2023 (structure data deposition date) |
![]() | Spiwokova, P. / Horn, M. / Fanfrlik, J. / Jilkova, A. / Fajtova, P. / Leontovyc, A. / Houstecka, R. / Bielikova, L. / Brynda, J. / Chanova, M. ...Spiwokova, P. / Horn, M. / Fanfrlik, J. / Jilkova, A. / Fajtova, P. / Leontovyc, A. / Houstecka, R. / Bielikova, L. / Brynda, J. / Chanova, M. / Mertlikova-Kaiserova, H. / Caro-Diaz, E.J.E. / Almaliti, J. / El-Sakkary, N. / Gerwick, W.H. / Caffrey, C.R. / Mares, M. |
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Methods | X-ray diffraction |
Resolution | 1.2 - 1.6 Å |
Structure data | ![]() PDB-8cc2: ![]() PDB-8ccu: ![]() PDB-8cd9: |
Chemicals | ![]() ChemComp-GN9: ![]() ChemComp-NA: ![]() ChemComp-HOH: ![]()
ChemComp-U9X: ![]()
ChemComp-UA9: ![]() ChemComp-EDO: |
Source |
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![]() | HYDROLASE / cysteine protease / cathepsin B / SmCB1 / Schistosoma mansoni / protease inhibitor peptidomimetic / gallinamide A |