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-Structure paper
Title | Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 79, Page 129050-129050, Year 2022 |
Publish date | Jul 15, 2022 (structure data deposition date) |
Authors | Imai, Y. / Wakasugi, D. / Suzuki, R. / Kato, S. / Sugisaki, M. / Mima, M. / Miyagawa, H. / Endo, M. / Fujimoto, N. / Fukunaga, T. ...Imai, Y. / Wakasugi, D. / Suzuki, R. / Kato, S. / Sugisaki, M. / Mima, M. / Miyagawa, H. / Endo, M. / Fujimoto, N. / Fukunaga, T. / Kuroda, S. / Takahashi, T. / Kakinuma, H. |
External links | Bioorg. Med. Chem. Lett. / PubMed:36368497 |
Methods | X-ray diffraction |
Resolution | 2.3 - 2.8 Å |
Structure data | PDB-7yi7: PDB-7yjc: |
Chemicals | ChemComp-IUV: ChemComp-HOH: ChemComp-IVO: |
Source |
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Keywords | HYDROLASE/INHIBITOR / Endo-glucoronidase / Heparanase-1 / HEP / HPA / HPA1 / HPR1 / HPSE1 / HSE1 / HYDROLASE / HYDROLASE-INHIBITOR complex |