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Structure paper

TitleCrystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold.
Journal, issue, pagesNucleic Acids Res., Vol. 50, Page 1000-1016, Year 2022
Publish dateJun 6, 2021 (structure data deposition date)
AuthorsTan, Y.B. / Lello, L.S. / Liu, X. / Law, Y.S. / Kang, C. / Lescar, J. / Zheng, J. / Merits, A. / Luo, D.
External linksNucleic Acids Res. / PubMed:35037043
MethodsX-ray diffraction
Resolution1.86 - 2.6 Å
Structure data

PDB-7f0s:
A crystal structure of alphavirus nonstructural protein 4 (nsP4) reveals an intrinsically 1dynamic RNA-dependent RNA polymerase
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-7vb4:
A crystal structure of alphavirus nonstructural protein 4 (nsP4) reveals an intrinsically dynamic RNA-dependent RNA polymerase
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

PDB-7vw5:
Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

Source
  • ross river virus (strain t48)
  • sindbis virus
KeywordsTRANSFERASE / RNA dependent RNA polymerase / RNA directed RNA polymerase / RdRp / Alphavirus / NSP4 / nonstructural protein 4

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