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Structure paper

TitleIdentification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.
Journal, issue, pagesEur. J. Med. Chem., Vol. 234, Page 114272-114272, Year 2022
Publish dateFeb 27, 2022 (structure data deposition date)
AuthorsZeyen, P. / Zeyn, Y. / Herp, D. / Mahmoudi, F. / Yesiloglu, T.Z. / Erdmann, F. / Schmidt, M. / Robaa, D. / Romier, C. / Ridinger, J. ...Zeyen, P. / Zeyn, Y. / Herp, D. / Mahmoudi, F. / Yesiloglu, T.Z. / Erdmann, F. / Schmidt, M. / Robaa, D. / Romier, C. / Ridinger, J. / Herbst-Gervasoni, C.J. / Christianson, D.W. / Oehme, I. / Jung, M. / Kramer, O.H. / Sippl, W.
External linksEur. J. Med. Chem. / PubMed:35306288
MethodsX-ray diffraction
Resolution2.1 - 2.6 Å
Structure data

PDB-7u3m:
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with N-methylpiperazine Benzhydroxamic Acid
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-7u69:
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Phenethyl Piperidine-4-acrylhydroxamic Acid Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-7u6a:
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 3-thienylmethyl Benzhydroxamic Acid Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-7u6b:
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Indolethyl Piperidine-4-acrylhydroxamic Acid Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-L8C:
N-hydroxy-4-[(4-methylpiperazin-1-yl)methyl]benzamide

ChemComp-ZN:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-LS6:
(2E)-N-hydroxy-3-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide

ChemComp-LSL:
N-hydroxy-4-({[(thiophen-3-yl)methyl]amino}methyl)benzamide

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-LTO:
(2E)-N-hydroxy-3-{1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl}prop-2-enamide

Source
  • danio rerio (zebrafish)
KeywordsHYDROLASE / Histone Deacetylase / HYDROLASE/INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex / HYDROLASE-INHIBITOR complex

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