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TitleAza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 144, Page 18861-18875, Year 2022
Publish dateOct 5, 2021 (structure data deposition date)
AuthorsSteimbach, R.R. / Herbst-Gervasoni, C.J. / Lechner, S. / Stewart, T.M. / Klinke, G. / Ridinger, J. / Geraldy, M.N.E. / Tihanyi, G. / Foley, J.R. / Uhrig, U. ...Steimbach, R.R. / Herbst-Gervasoni, C.J. / Lechner, S. / Stewart, T.M. / Klinke, G. / Ridinger, J. / Geraldy, M.N.E. / Tihanyi, G. / Foley, J.R. / Uhrig, U. / Kuster, B. / Poschet, G. / Casero Jr., R.A. / Medard, G. / Oehme, I. / Christianson, D.W. / Gunkel, N. / Miller, A.K.
External linksJ. Am. Chem. Soc. / PubMed:36200994
MethodsX-ray diffraction
Resolution2.1 - 2.2 Å
Structure data

PDB-7sgg:
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with SAHA
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-7sgi:
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Inhibitor 14
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-7sgj:
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-711
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-7sgk:
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-728
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-SHH:
OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-ZN:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-9DL:
5-[(2-anilino-2-oxoethyl)(methyl)amino]-N-hydroxypentanamide

ChemComp-9BI:
4-[(3-anilino-3-oxopropyl)(methyl)amino]-N-hydroxybutanamide

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-9A9:
N-(2-{[4-(hydroxyamino)-4-oxobutyl](methyl)amino}ethyl)benzamide

Source
  • danio rerio (zebrafish)
KeywordsHYDROLASE / Histone Deacetylase

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