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-Structure paper
Title | Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 1928-1940, Year 2023 |
Publish date | Aug 19, 2021 (structure data deposition date) |
Authors | Faber, E.B. / Wang, N. / John, K. / Sun, L. / Wong, H.L. / Burban, D. / Francis, R. / Tian, D. / Hong, K.H. / Yang, A. ...Faber, E.B. / Wang, N. / John, K. / Sun, L. / Wong, H.L. / Burban, D. / Francis, R. / Tian, D. / Hong, K.H. / Yang, A. / Wang, L. / Elsaid, M. / Khalid, H. / Levinson, N.M. / Schonbrunn, E. / Hawkinson, J.E. / Georg, G.I. |
External links | J. Med. Chem. / PubMed:36701569 |
Methods | X-ray diffraction |
Resolution | 1.38 - 1.98 Å |
Structure data | PDB-7rwe: PDB-7rxo: PDB-7s4t: PDB-7s7a: PDB-7s85: |
Chemicals | ChemComp-7TH: ChemComp-HOH: ChemComp-EDO: ChemComp-80E: ChemComp-88O: ChemComp-8FI: ChemComp-8IQ: |
Source |
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Keywords | CELL CYCLE / allosteric inhibitor / drug development / kinase / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex / cyclin dependent kinase |