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TitleInsights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison.
Journal, issue, pagesInt J Mol Sci, Vol. 22, Year 2021
Publish dateJul 23, 2021 (structure data deposition date)
AuthorsParikh, S.J. / Kamat, S. / Phillips, M. / Boyson, S.P. / Yarbrough, T. / Davie, D. / Zhang, Q. / Glass, K.C. / Shah, M.B.
External linksInt J Mol Sci / PubMed:34638547
MethodsX-ray diffraction
Resolution2.23 Å
Structure data

PDB-7rl2:
Crystal Structure of the Human Cytochrome P450 2C9*8 (CYP2C9*8) Genetic Variant in Complex with the Drug Losartan
Method: X-RAY DIFFRACTION / Resolution: 2.23 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-LSN:
[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol / medication*YM

ChemComp-K:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Cytochrome P450 / CYP2C9

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