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TitleA KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 144, Page 22493-22504, Year 2022
Publish dateDec 6, 2021 (structure data deposition date)
AuthorsZhang, L. / Lovell, S. / De Vita, E. / Jagtap, P.K.A. / Lucy, D. / Goya Grocin, A. / Kjaer, S. / Borg, A. / Hennig, J. / Miller, A.K. / Tate, E.W.
External linksJ. Am. Chem. Soc. / PubMed:36413626
MethodsX-ray diffraction
Resolution1.47 - 1.56 Å
Structure data

PDB-7qft:
Crystal structure of KLK6 in complex with compound 16a
Method: X-RAY DIFFRACTION / Resolution: 1.47 Å

PDB-7qfv:
Crystal structure of KLK6 in complex with compound 17a
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsPEPTIDE BINDING PROTEIN / serine proteases

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