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-Structure paper
Title | An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides. |
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Journal, issue, pages | Nat Commun, Vol. 13, Page 4036-4036, Year 2022 |
Publish date | Mar 4, 2021 (structure data deposition date) |
![]() | Baker, Y.R. / Thorpe, C. / Chen, J. / Poller, L.M. / Cox, L. / Kumar, P. / Lim, W.F. / Lie, L. / McClorey, G. / Epple, S. ...Baker, Y.R. / Thorpe, C. / Chen, J. / Poller, L.M. / Cox, L. / Kumar, P. / Lim, W.F. / Lie, L. / McClorey, G. / Epple, S. / Singleton, D. / McDonough, M.A. / Hardwick, J.S. / Christensen, K.E. / Wood, M.J.A. / Hall, J.P. / El-Sagheer, A.H. / Brown, T. |
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Methods | X-ray diffraction |
Resolution | 2.57 - 2.7 Å |
Structure data | ![]() PDB-7nrp: ![]() PDB-7ooo: ![]() PDB-7oos: ![]() PDB-7ozz: |
Chemicals | ![]() ChemComp-CAC: ![]() ChemComp-HOH: ![]() ChemComp-MG: ![]() ChemComp-SR: ![]() ChemComp-K: |
Source |
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![]() | DNA-RNA HYBRID / Amide-LNA / duplex / DNA:RNA / unmodified / DNA:RNA HYBRID |