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-Structure paper
Title | Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 11432-11444, Year 2021 |
Publish date | Apr 16, 2020 (structure data deposition date) |
Authors | Plyasova, A.A. / Berrino, E. / Khan, I.I. / Veselovsky, A.V. / Pokrovsky, V.S. / Angeli, A. / Ferraroni, M. / Supuran, C.T. / Pokrovskaya, M.V. / Alexandrova, S.S. ...Plyasova, A.A. / Berrino, E. / Khan, I.I. / Veselovsky, A.V. / Pokrovsky, V.S. / Angeli, A. / Ferraroni, M. / Supuran, C.T. / Pokrovskaya, M.V. / Alexandrova, S.S. / Gladilina, Y.A. / Sokolov, N.N. / Hilal, A. / Carta, F. / Zhdanov, D.D. |
External links | J. Med. Chem. / PubMed:34283610 |
Methods | X-ray diffraction |
Resolution | 1.1 - 1.28 Å |
Structure data | PDB-6ypw: PDB-7nh6: |
Chemicals | ChemComp-ZN: ChemComp-P75: ChemComp-HOH: ChemComp-GOL: ChemComp-UDE: |
Source |
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Keywords | LYASE / Carbonic Anhydrase Inhibitors; AZT; Telomerase Inhibitors; Cancer; Molecular hybrids; Click Chemistry; Triazole. / carbonic anhydrase II / inhibitor / metalloenzyme / sulfonamide |