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Title | Peptidomimetic alpha-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 2905-2925, Year 2022 |
Publish date | Mar 31, 2021 (structure data deposition date) |
![]() | Bai, B. / Belovodskiy, A. / Hena, M. / Kandadai, A.S. / Joyce, M.A. / Saffran, H.A. / Shields, J.A. / Khan, M.B. / Arutyunova, E. / Lu, J. ...Bai, B. / Belovodskiy, A. / Hena, M. / Kandadai, A.S. / Joyce, M.A. / Saffran, H.A. / Shields, J.A. / Khan, M.B. / Arutyunova, E. / Lu, J. / Bajwa, S.K. / Hockman, D. / Fischer, C. / Lamer, T. / Vuong, W. / van Belkum, M.J. / Gu, Z. / Lin, F. / Du, Y. / Xu, J. / Rahim, M. / Young, H.S. / Vederas, J.C. / Tyrrell, D.L. / Lemieux, M.J. / Nieman, J.A. |
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Methods | X-ray diffraction |
Resolution | 2.15 Å |
Structure data | ![]() PDB-7mbi: |
Chemicals | ![]() ChemComp-YWJ: ![]() ChemComp-FN7: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / viral protein / HYDROLASE-HYDROLASE INHIBITOR complex |