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-Structure paper
Title | Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 6902-6923, Year 2021 |
Publish date | Nov 29, 2020 (structure data deposition date) |
Authors | Vyskocil, S. / Cardin, D. / Ciavarri, J. / Conlon, J. / Cullis, C. / England, D. / Gershman, R. / Gigstad, K. / Gipson, K. / Gould, A. ...Vyskocil, S. / Cardin, D. / Ciavarri, J. / Conlon, J. / Cullis, C. / England, D. / Gershman, R. / Gigstad, K. / Gipson, K. / Gould, A. / Greenspan, P. / Griffin, R. / Gulavita, N. / Harrison, S. / Hu, Z. / Hu, Y. / Hata, A. / Huang, J. / Huang, S.C. / Janowick, D. / Jones, M. / Kolev, V. / Langston, S.P. / Lee, H.M. / Li, G. / Lok, D. / Ma, L. / Mai, D. / Malley, J. / Matsuda, A. / Mizutani, H. / Mizutani, M. / Molchanova, N. / Nunes, E. / Pusalkar, S. / Renou, C. / Rowland, S. / Sato, Y. / Shaw, M. / Shen, L. / Shi, Z. / Skene, R. / Soucy, F. / Stroud, S. / Xu, H. / Xu, T. / Abu-Yousif, A.O. / Zhang, J. |
External links | J. Med. Chem. / PubMed:34000802 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.48 Å |
Structure data | PDB-7kvx: PDB-7kvz: PDB-7kw1: |
Chemicals | ChemComp-X5J: ChemComp-HOH: ChemComp-X5D: ChemComp-X4M: |
Source |
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Keywords | IMMUNE SYSTEM / immunotherapy / stimulator of interferon genes / cyclic dinucleotide |