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Title | PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease. |
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Journal, issue, pages | J. Med. Chem., Vol. 64, Page 326-342, Year 2021 |
Publish date | Aug 28, 2020 (structure data deposition date) |
Authors | Gopalsamy, A. / Aulabaugh, A.E. / Barakat, A. / Beaumont, K.C. / Cabral, S. / Canterbury, D.P. / Casimiro-Garcia, A. / Chang, J.S. / Chen, M.Z. / Choi, C. ...Gopalsamy, A. / Aulabaugh, A.E. / Barakat, A. / Beaumont, K.C. / Cabral, S. / Canterbury, D.P. / Casimiro-Garcia, A. / Chang, J.S. / Chen, M.Z. / Choi, C. / Dow, R.L. / Fadeyi, O.O. / Feng, X. / France, S.P. / Howard, R.M. / Janz, J.M. / Jasti, J. / Jasuja, R. / Jones, L.H. / King-Ahmad, A. / Knee, K.M. / Kohrt, J.T. / Limberakis, C. / Liras, S. / Martinez, C.A. / McClure, K.F. / Narayanan, A. / Narula, J. / Novak, J.J. / O'Connell, T.N. / Parikh, M.D. / Piotrowski, D.W. / Plotnikova, O. / Robinson, R.P. / Sahasrabudhe, P.V. / Sharma, R. / Thuma, B.A. / Vasa, D. / Wei, L. / Wenzel, A.Z. / Withka, J.M. / Xiao, J. / Yayla, H.G. |
External links | J. Med. Chem. / PubMed:33356244 |
Methods | X-ray diffraction |
Resolution | 1.48 - 2.23 Å |
Structure data | PDB-7jxz: PDB-7jy0: PDB-7jy1: PDB-7jy3: |
Chemicals | ChemComp-HEM: ChemComp-CMO: ChemComp-O4B: ChemComp-VOJ: ChemComp-GOL: ChemComp-HOH: ChemComp-VOM: ChemComp-VOP: ChemComp-OXY: ChemComp-VUD: |
Source |
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Keywords | OXYGEN TRANSPORT / hemoglobin |