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| Title | Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 64, Page 6358-6380, Year 2021 |
| Publish date | Aug 28, 2020 (structure data deposition date) |
 Authors | Halkina, T. / Henderson, J.L. / Lin, E.Y. / Himmelbauer, M.K. / Jones, J.H. / Nevalainen, M. / Feng, J. / King, K. / Rooney, M. / Johnson, J.L. ...Halkina, T. / Henderson, J.L. / Lin, E.Y. / Himmelbauer, M.K. / Jones, J.H. / Nevalainen, M. / Feng, J. / King, K. / Rooney, M. / Johnson, J.L. / Marcotte, D.J. / Chodaparambil, J.V. / Kumar, P.R. / Patterson, T.A. / Murugan, P. / Schuman, E. / Wong, L. / Hesson, T. / Lamore, S. / Bao, C. / Calhoun, M. / Certo, H. / Amaral, B. / Dillon, G.M. / Gilfillan, R. / de Turiso, F.G. |
 External links | J. Med. Chem. / PubMed:33944571 |
| Methods | X-ray diffraction |
| Resolution | 1.56 - 2.15 Å |
| Structure data |  PDB-7jxx:  PDB-7jxy: |
| Chemicals |  ChemComp-VP7:  ChemComp-NA:  ChemComp-HOH:  ChemComp-VSY: |
| Source |
|
 Keywords | TRANSFERASE/INHIBITOR / tau tubulin binding kinase / kinase / TRANSFERASE / TRANSFERASE-INHIBITOR complex |
homo sapiens (human)