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-Structure paper
Title | XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 119, Year 2022 |
Publish date | Aug 20, 2020 (structure data deposition date) |
Authors | Principe, D.R. / Xiong, R. / Li, Y. / Pham, T.N.D. / Kamath, S.D. / Dubrovskyi, O. / Ratia, K. / Huang, F. / Zhao, J. / Shen, Z. ...Principe, D.R. / Xiong, R. / Li, Y. / Pham, T.N.D. / Kamath, S.D. / Dubrovskyi, O. / Ratia, K. / Huang, F. / Zhao, J. / Shen, Z. / Thummuri, D. / Daohong, Z. / Underwood, P.W. / Trevino, J. / Munshi, H.G. / Thatcher, G.R.J. / Rana, A. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:35064087 |
Methods | X-ray diffraction |
Resolution | 2.2 Å |
Structure data | PDB-7juo: |
Chemicals | ChemComp-YF2: ChemComp-HOH: |
Source |
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Keywords | TRANSCRIPTION / Dual BET/CBP inhibitor |